Prof.
Dr. Nesrin Gülez
Branşı: Çocuk Sağlığı ve Hastalıkları, Çocuk İmmünoloji Uzmanı
Yabancı
Diller: İngilizce
İletişim
adresi:……..@saglik.gov.tr
Klinik:
Çocuk
Alerji-İmmünoloji Kliniği Eğitim Görevlisi
Tıbbi
ilgi ve uzmanlık alanları:
……………..
Eğitimi:
2011 Ege
Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları AD Çocuk İmmunolojisi
1998 Dr.
Behçet Uz Çocuk Hastalıkları Ve Cerrahisi Eğitim ve Araştırma Hastanesi
1992 Ege Üniversitesi Tıp Fakültesi
Çalışılan
Kurumlar:
1992/1993 Çorum Merkez Ana Çocuk Sağlığı Merkezi
1993/1998 Dr. Behçet Uz Çocuk Hastalıkları Ve Cerrahisi Eğitim ve Araştırma Hastanesi
1998/2001 Karşıyaka Ana Çocuk Sağlığı Merkezi
2001/2007 Dr. Behçet Uz Çocuk Hastalıkları
Ve Cerrahisi Eğitim ve Araştırma Hastanesi
2007/2011 Ege Üniversitesi Tıp
Fakültesi Çocuk Sağlığı ve Hastalıkları AD Çocuk İmmunolojisi
2011/…..
Dr. Behçet Uz Çocuk Hastalıkları Ve Cerrahisi Eğitim ve Araştırma Hastanesi Çocuk İmmünoloji Kliniği
Yayınlar:
Uluslararası hakemli dergilerde yayınlanan makaleler
(SCI & SSCI & Arts and Humanities)
1: Hortu HO, Karaca E, Sozeri B, Gulez N, Makay B,
Gunduz C, Atik T, Tekin IM, Unsal SE, Cogulu O. Correction to: Evaluation of
the effects of miRNAs in familial Mediterranean fever. Clin Rheumatol. 2019 Jan
7. doi:10.1007/s10067-018-04409-w. [Epub ahead of print] PubMed PMID: 30617595.
2: Genel F, Erdem SB, Gülez N, Karaman S, Nacaroglu
HT, Skattum L, Truedsson L.Inherited Classical and Alternative Pathway
Complement Deficiencies in Children: A Single Center Experience. Iran J
Immunol. 2018 Dec;15(4):309-320. doi:10.22034/IJI.2018.39400. PubMed PMID:
30593745.
3: Gülez N, Makay B, Sözeri B. Long-Term
Effectıveness and Safety of Canakınumab ın Pedıatrıc Famılıal Medıterranean
fever patıents. Mod Rheumatol. 2018 Dec 17:1-13. doi: 10.1080/14397595.2018.1559488.
[Epub ahead of print] PubMed PMID:30556769.
4: Karaca NE, Severcan EU, Bilgin BG, Azarsiz E,
Akarcan S, Gunaydın NC, Gulez N,Genel F, Aksu G, Kutukculer N. Familial
inheritance and screening of first-degree relatives in common variable
immunodeficiency and immunoglobulin A deficiency patients. Int J Immunopathol
Pharmacol. 2018 Jan-Dec;32:2058738418779458. doi: 10.1177/2058738418779458.
PubMed PMID: 29978731; PubMed
5: Pfajfer L, Mair NK, Jiménez-Heredia R, Genel F,
Gulez N, Ardeniz Ö, Hoeger B, Bal SK, Madritsch C, et al.
Mutations affecting the actin regulator WD
repeat-containing protein 1 lead to aberrant lymphoid immunity. J Allergy Clin
Immunol. 2018Nov;142(5):1589-1604.e11. doi: 10.1016/j.jaci.2018.04.023. Epub
2018 May 8.
6: Karaman S, Erdem SB, Gülez N, Genel F. The
Significance of B-cell Subsets in Patients with Unclassified
Hypogammaglobulinemia and Association with Intravenous Immunoglobulin
Replacement Requirement. Iran J Immunol. 2018 Mar;15(1):1-13. doi:IJIv15i1A1. PubMed
PMID: 29549228.
7: Hortu HO, Karaca E, Sozeri B, Gulez N, Makay B,
Gunduz C, Atik T, Tekin IM,Unsal SE, Cogulu O. Evaluation of the effects of
miRNAs in familial Mediterranean fever. Clin Rheumatol. 2018 Feb 13. doi:
10.1007/s10067-017-3914-0. [Epub ahead of print] Erratum in: Clin Rheumatol.
2019 Jan 7;:. PubMed PMID: 29442258.
8: Makay B, Gülez N. Long-term follow-up of
paediatric MEFV carriers. Clin Rheumatol. 2018 Jun;37(6):1683-1687. doi:
10.1007/s10067-017-3883-3. Epub 2017Nov 3. PubMed PMID: 29101676.
9: Nacaroğlu HT, Bahçeci Erdem S, Gülez N, Ünsal
Karkıner CŞ, Devrim İ, Genel F, Köker MY, Can D. Tuberculosis masked by
immunodeficiency: a review of two cases diagnosed with chronic granulomatous
disease. Tuberk Toraks. 2017 Mar;65(1):56-59. PubMed PMID: 28621249.
10: Kundak S, Bağ Ö, Gülez N, Ergin M. A child with
subcorneal pustular dermatosis responded to IVIG treatment (Sneddon-Wilkinson
disease). Reumatologia. 2017;55(6):323-327. doi: 10.5114/reum.2017.72631. Epub
2017 Dec 30. PubMed PMID: 29491542;
11: Karaca NE, Aksu G, Ulusoy E, Aksoylar S, Gozmen
S, Genel F, Akarcan S, Gulez N, Hirschmugl T, Kansoy S, Boztug K, Kutukculer N.
Early Diagnosis and Hematopoietic Stem Cell Transplantation for IL10R
Deficiency Leading to Very Early-Onset Inflammatory Bowel Disease Are Essential
in Familial Cases. Case
Reports Immunol. 2016;2016:5459029. Epub 2016 Sep 6.
12: Sozeri B, Gulez N, Ergin M, Serdaroglu E. The
experience of canakinumab in renal amyloidosis secondary to Familial
Mediterranean fever. Mol Cell Pediatr.2016 Dec;3(1):33. doi:
10.1186/s40348-016-0058-2. Epub 2016 Aug 15.
13: Keles S, Charbonnier LM, Kabaleeswaran V, Reisli
I, Genel F, Gulez N, Al-Herz W, Ramesh N, Perez-Atayde A, Karaca NE, Kutukculer
N, Wu H, Geha RS, Chatila TA. Dedicator of cytokinesis 8 regulates signal
transducer and activator of transcription 3 activation and promotes T(H)17 cell
differentiation. J Allergy
Clin Immunol. 2016 Nov;138(5):1384-1394.e2. doi:
10.1016/j.jaci.2016.04.023. Epub 2016 May 24. PubMed PMID: 27350570; PubMed
Central PMCID: PMC5099100.
14: Polat A, Acikel C, Sozeri B, Dursun I,
Kasapcopur O, Gulez N, Simsek D,Saldir M, Dokurel I, Poyrazoglu H, Bakkaloglu
S, Delibas A, Ekinci Z, Ayaz NA,Kandur Y, Peru H, Kurt YG, Polat SR, Unsal E,
Makay B, Gok F, Ozen S, Demirkaya E; FMF Arthritis Vasculitis and Orphan
Disease Research in Pediatric Rheumatology
(FAVOR). Comparison of the efficacy of once- and
twice-daily colchicine dosage in pediatric patients with familial Mediterranean
fever--a randomized controlled noninferiority trial. Arthritis Res Ther. 2016
Apr 7;18:85. doi: 10.1186/s13075-016-0980-7. PubMed PMID: 27055417;
15: Erdem SB, Genel F, Erdur B, Ozbek E, Gulez N,
Mese T. Asplenia in children with congenital heart disease as a cause of poor
outcome. Cent Eur J Immunol. 2015;40(2):266-9. doi:
10.5114/ceji.2015.52841. Epub 2015 Aug 3.
16: Bahceci SE, Genel F, Gulez N, Nacaroglu
HT. Coexistence of hereditary angioedema in a case of familial
Mediterranean fever with partial response to colchicine. Cent Eur J Immunol.
2015;40(1):115-6. doi: 10.5114/ceji.2015.50843.Epub 2015 Apr 22. PubMed PMID:
26155193; .
17: Azarsiz E, Karaca NE, Gunaydin NC, Gulez N,
Ozturk C, Aksu G, Genel F,Kutukculer N. Do elevated serum IgM levels have to be
included in probablediagnosis criteria of patients with ataxia-telangiectasia?
Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(3):421-7. PubMed PMID: 25280033.
18: Yılmaz U, Gülez N, Cubukçu D, Güzel O, Akinci G,
Oztürk A. Recurrent peripheral facial palsy in a child with familial
Mediterranean fever. Pediatr Neurol. 2013 Oct;49(4):289-91. doi:
10.1016/j.pediatrneurol.2013.05.003. Epub2013 Jul 6. PubMed PMID: 23838413.
19: Kutukculer N, Gulez N, Karaca NE, Aksu G,
Berdeli A. Three different classifications, B lymphocyte subpopulations,
TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CTLA-4
and ICOS gene polymorphisms in Turkish patients with common variable
immunodeficiency. J Clin Immunol. 2012Dec;32(6):1165-79. doi:
10.1007/s10875-012-9717-9. Epub 2012 Jun 15.
20: Kutukculer N, Gulez N, Karaca NE, Aksu G,
Berdeli A. Novel mutatıons and diverse clinical phenotypes in
recombinase-activating gene 1 deficiency. Ital J Pediatr. 2012 Mar 16;38:8.
doi: 10.1186/1824-7288-38-8. PubMed PMID: 22424479; PubMed Central PMCID:
PMC3394211.
21: Sozeri B, Gulez N, Aksu G, Kutukculer N, Akalın
T, Kandiloglu G.Pesticide-induced scleroderma and early intensive
immunosuppressive treatment.Arch Environ Occup Health. 2012;67(1):43-7. doi:
10.1080/19338244.2011.564231.PubMed PMID: 22315935.
22: Ozturk C, Halicioglu O, Coker I, Gulez N,
Sutçuoglu S, Karaca N, Aksu G,Kutukculer N. Association of clinical and
genetical features in FMF with focus on MEFV strip assay sensitivity in 452
children from western Anatolia, Turkey. Clin Rheumatol. 2012 Mar;31(3):493-501.
doi: 10.1007/s10067-011-1876-1. Epub 2011 Nov 5. PubMed PMID: 22057232.
23: Genel F, Atlihan F, Gulez N, Kazanci E, Vergin
C, Terek DT, Yurdun OC.Evaluation of adhesion molecules CD64, CD11b and CD62L
in neutrophils and monocytes of peripheral blood for early diagnosis of
neonatal infection. World J Pediatr. 2012 Feb;8(1):72-5. doi:
10.1007/s12519-011-0304-6. Epub 2011 Aug 27.
24: Karaca NE, Gulez N, Aksu G, Azarsiz E,
Kutukculer N. Does OM-85 BV prophylaxis trigger autoimmunity in IgA deficient
children? Int Immunopharmacol. 2011 Nov;11(11):1747-51. doi:
10.1016/j.intimp.2011.06.009. Epub 2011 Jul 21.PubMed PMID: 21771668.
25: Kutulculer N, Karaca NE, Azarsiz E, Aksu G,
Gulez N. Immunoglobulin light chain levels can be used to determine disease
stage in children with juvenile idiopathic arthritis. Clin Lab Sci. 2011
Spring;24(2):93-8. PubMed PMID:21657141.
26: Gulez N, Aksu G, Berdeli A, Karaca N, Tanrıverdi
S, Kutukculer N, Azarsiz E. X-Linked Lymphoproliferative Syndrome and Common
Variable Immunodeficiency MayNot Be Differentiated by SH2D1A and XIAP/BIRC4
Genes Sequence Analysis. Case Rep Med. 2011;2011:121258. doi:
10.1155/2011/121258. Epub 2011 Apr 12. PubMed PMID:21541208;
27: Karaca NE, Durandy A, Gulez N, Aksu G,
Kutukculer N. Study of patients with Hyper-IgM type IV phenotype who recovered
spontaneously during late childhood and review of the literature. Eur J
Pediatr. 2011 Aug;170(8):1039-47. doi:10.1007/s00431-011-1400-2. Epub 2011 Jan
28. Review.
28: Karaca NE, Aksu G, Gulez N, Yildiz B, Azarsiz E,
Kutukculer N. New laboratory findings in Turkish patients with transient hypogammaglobulinemia
of infancy. Iran J Allergy Asthma Immunol. 2010 Dec;9(4):237-43. doi:
09.04/ijaai.237243. PubMed PMID: 21131704.
29: Karaca N, Aksu G, Ozturk C, Gulez N, Kutukculer
N. Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis
triggered by vaccinations in a two-year-old boy: a case report. J Med Case Rep.
2010 Oct 18;4:325. doi:10.1186/1752-1947-4-325. PubMed PMID: 20955551;
30: Azarsiz E, Gulez N, Edeer Karaca N, Aksu G,
Kutukculer N. Consanguinity rate and delay in diagnosis in Turkish patients
with combined immunodeficiencies: a single-center study. J Clin Immunol. 2011
Feb;31(1):106-11. doi:10.1007/s10875-010-9472-8. Epub 2010 Oct 6. PubMed PMID:
20924659.
31: Gulez N, Genel F, Atlihan F, Gullstrand B,
Skattum L, Schejbel L, Garred P,Truedsson L. Homozygosity for a novel mutation
in the C1q C chain gene in a Turkish family with hereditary C1q deficiency. J
Investig Allergol Clin Immunol. 2010;20(3):255-8. PubMed PMID: 20635792.
32: Aksu G, Gulez N, Azarsiz E, Karaca N, Kutukçuler
N. Determination of cut-off titers and agreement between immunofluorescence and
immunoblotting methods for detecting antinuclear antibodies in children. J Clin
Lab Anal. 2010;24(4):230-6. doi: 10.1002/jcla.20391. PubMed PMID: 20626019.
33: Edeer-Karaca N, Gülez N, Aksu G, Kütükcüler N.
Common variable immunodeficiency: familial inheritance and autoimmune
manifestations in two siblings. Turk J Pediatr. 2010 Jan-Feb;52(1):89-93.
PubMed PMID: 20402074.
34: Kutukculer N, Gulez N, Karaca N, Aksu G, Berdeli
A. A novel Y331X nonsensenmutation in TNFRSF1A gene in two unrelated Turkish
families with periodic fever syndrome. Int J Immunogenet. 2010 Feb;37(1):21-5.
doi:10.1111/j.1744-313X.2009.00884.x. Epub 2009 Oct 5. PubMed PMID: 19804406.
35: Karaca NE, Aksu G, Genel F, Gulez N, Can S,
Aydinok Y, Aksoylar S, Karaca E, Altuglu I, Kutukculer N. Diverse phenotypic
and genotypic presentation of RAG1 mutations in two cases with SCID. Clin Exp
Med. 2009 Dec;9(4):339-42. doi: 10.1007/s10238-009-0053-1. Epub 2009 May 21.
PubMed PMID: 19458910.
36: Karaca NE, Aksu G, Yildiz B, Gulez N, Turk B,
Dereli T, Kutukculer N. Relapsing polychondritis in a child with common
variable immunodeficiency. Int J Dermatol. 2009 May;48(5):525-8. doi:
10.1111/j.1365-4632.2009.03809.x.
37: Kutukculer N, Gulez N. The outcome of patients
with unclassified hypogammaglobulinemia in early childhood. Pediatr Allergy
Immunol. 2009 Nov;20(7):693-8. doi: 10.1111/j.1399-3038.2008.00845.x. Epub 2009
Jan 31. PubMed PMID: 19196447.
38: Gulez N, Karaca NE, Aksu G, Kutukculer N.
Increased percentages of autoantibodies in immunoglobulin A-deficient children
do not correlate with clinical manifestations. Autoimmunity. 2009
Jan;42(1):74-9. doi: 10.1080/08916930802375711. PubMed PMID: 19127458.
39: Genel F, Atlihan F, Gulez N, Sjöholm AG, Skattum
L, Truedsson L. Properdin deficiency in a boy with fulminant meningococcal
septic shock. Acta Paediatr. 2006 Nov;95(11):1498-1500. PubMed PMID: 17062484.
40: Genel F, Atlihan F, Targan S, Gulez N, Hacikara
S, Karaca I. Fulminant amoebiasis in a child with recurrent multiple amoebic
liver abscesses and pleuropulmonary complications. Ann Trop Paediatr. 2004
Sep;24(3):267-9.