Doç. Dr. Filiz Hazan
Branşı: Tıbbi Genetik Uzmanı
Yabancı Diller: İngilizce
İletişim adresi: …..@saglik.gov.tr
Klinik: Genetik Hastalıklar Tanı Merkezi
Tıbbi ilgi ve uzmanlık alanları:
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Eğitimi:
2010 Uzmanlık, Ege Üniversitesi Tıp Fakültesi, Tıbbi Genetik ABD
2000 Lisans, Dokuz Eylül Üniversitesi Tıp Fakültesi
Çalışılan Kurumlar:
2001/2002 Afyon Dinar Devlet Hastanesi, Pratisyen Hekim
2002/2004 İzmir MTK Sitesi Sağlık Ocağı, Pratisyen Hekim
2004/2010 Ege Üniversitesi Tıp Fakültesi, Tıbbi Genetik ABD, Asistanlık Eğitimi
2010/…. S.B.Ü İzmir Dr. Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim ve Araştırma Hastanesi Genetik Hastalıkları Tanı Merkezi, Tıbbi Genetik Uzmanı
Yayınlar:
1- Durmaz B, Wollnik B, Cogulu O, Li Y, Tekgul H, Hazan F, Ozkinay F Pontocerebellar hypoplasia type III (CLAM): extended phenotype and novel molecular findings.J Neurol. 2009;256(3):416-9.
2- Hazan F, Aykut A, Hizarcioglu M, Tavli V, Onay H, Ozkinay F. A Cardio-Facio-Cutaneous Syndrome Case with Tight Achilles Tendons. Genet Couns. 2012;23(2):305-11.
3- Hazan F, Ostergaard P, Ozturk T, Kantekin E, Atlihan F, Jeffery S, Ozkinay F. A Novel KIF11 Mutation in a Turkish Patient with Microcephaly, Lymphedema, and Chorioretinal Dysplasia from a consanguineous family. Am J Med Genet A. 2012;158A(7):1686-9.
4- Zampieri S, Cattarossi S, Oller Ramirez AM, Rosano C, Lourenco CM, Passon N, Moroni I, Uziel G, Pettinari A, Stanzial F, de Kremer RD, Azar NB, Hazan F, Filocamo M, Bembi B, Dardis A. Sequence and copy number analyses of HEXB gene in patients affected by Sandhoff disease: functional characterization of 9 novel sequence variants. PLoS One. 2012;7(7):e41516.
5- Korkmaz HA, Hazan F, Dizdarer C, Tükün A. Hypochondroplasia in a child with 1620C>G (Asn540Lys) mutation in FGFR3. J Clin Res Pediatr Endocrinol 2012:220-2.
6- Hazan F, Aykut A, Unalp A, Mese T, Unal N, Onay H, Ozkinay F. Ventricular septal defect in Crouzon Syndrome: case report. Genet Couns. 2012;23(4):519-22.
7- Hazan F, Ozturk AT, Adibelli H, Unal N, Tukun A. A novel missense mutation of the paired box 3 gene in a Turkish family with Waardenburg syndrome type 1. Mol Vis. 2013;19:196-202.
8- Korkmaz HA, Özkan B, Hazan F, Büyükinan M, Çelik T. A case of Turner syndrome with concomitant transient hypogammaglobulinaemia of infancy and central diabetes insipidus. J Clin Res Pediatr Endocrinol 2013;5:62-4.
9- Korkmaz HA, Dizdarer C, Hazan F, Karaarslan U. Attempted suicide with levothyroxine in an adolescent girl. J Pediatr Endocrinol Metab 2013;26:129-31.
10- Zeytinoglu M, Aykut A, Hazan F, Torrente I, Akay MC, Karapinar DY, Vergin C, Cogulu O, Ozkinay F. A novel mutation, IVS13+5G>A, in Ellis-van Creveld syndrome associated with haemophagocytic lymphohistiocytosis. Clin Dysmorphol. 2013;22(4):140-2.
11- Jones GE, Ostergaard P, Moore AT, Connell FC, Williams D, Quarrell O, Brady AF, Spier I, Hazan F, Moldovan O, Wieczorek D, Mikat B, Petit F, Coubes C, Saul RA, Brice G, Gordon K, Jeffery S, Mortimer PS, Vasudevan PC, Mansour S. Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations. Eur J Hum Genet. 2014;22(7):881-7.
12- Dınız G, Hazan F, Yildirim HT, Unalp A, Polat M, Serdaroğlu G, Güzel O, Bağ O, Seçıl Y, Ozgönül F, Türe S, Akhan G, Tükün A. Histopathological and genetic features of patients with limb girdle muscular dystrophy type 2C. Turk Patoloji Derg. 2014;30(2):111-7.
13- Diniz G, Tosun Yildirim H, Akinci G, Hazan F, Ozturk A, Yararbas K, Tukun A. Sarcolemmal alpha and gamma sarcoglycan protein deficiencies in Turkish siblings with a novel missense mutation in the alpha sarcoglycan gene. Pediatr Neurol. 2014;50(6):640-7.
14- Hazan F, Karaca E, Koker SA, Korkmaz HA, Mese T, Onay H, Ozkinay F. A Novel Missense Mutation in BRAF Caused Cardio-Facio-Cutaneous Syndrome. Iran J Pediatr. 2013;23(5):608-9.
15- Diniz G, Tosun Yildirim H, Gokben S, Serdaroglu G, Hazan F, Yararbas K, Tukun A. Concomitant alpha- and gamma-sarcoglycan deficiencies in a Turkish boy with a novel deletion in the alpha-sarcoglycan gene. Case Rep Genet. 2014; 2014:248561.
16- Wieczorek D, Newman WG, Wieland T, Berulava T, Kaffe M, Falkenstein D, Beetz C, Graf E, Schwarzmayr T, Douzgou S, Clayton-Smith J, Daly SB, Williams SG, Bhaskar SS, Urquhart JE, Anderson B, O'Sullivan J, Boute O, Gundlach J, Czeschik JC, van Essen AJ, Hazan F, Park S, Hing A, Kuechler A, Lohmann DR, Ludwig KU, Mangold E, Steenpaß L, Zeschnigk M, Lemke JR, Lourenco CM, Hehr U, Prott EC, Waldenberger M, Böhmer AC, Horsthemke B, O'Keefe RT, Meitinger T, Burn J, Lüdecke HJ, Strom TM. Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome. Am J Hum Genet. 2014;95(6):698-707.
17- Demir K, Yıldız M, Elmas ÖN, Korkmaz HA, Tunç S, Olukman Ö, Hazan F, Özkan KU, Özkan B. Two different patterns of mini-puberty in two 46,XY newborns with 17β-hydroxysteroid dehydrogenase type 3 deficiency. J Pediatr Endocrinol Metab. 2015;28(7-8):961-5.
18- Karapinar TH, Oymak Y, Ay Y, Köker SA, Töret E, Hazan F, Vergin C. Chronic Neutropenia in Childhood: Experience From a Single Center.J Pediatr Hematol Oncol. 2015;16. [Epub ahead of print].
19- Ece Solmaz A, Onay H, Atik T, Aykut A, Cerrah Gunes M, Ozalp Yuregir O, Bas VN, Hazan F, Kirbiyik O, Ozkinay F. Targeted multi-gene panel testing for the diagnosis of Bardet Biedl Syndrome: Identification of nine novel mutations across BBS1, BBS2, BBS4, BBS7, BBS9, BBS10 genes. Eur J Med Genet. 2015. [Epub ahead of print].
20- Cogulu D, Hazan F, Dindaroglu FC. OROFACIAL FINDINGS AND DENTAL MANAGEMENT OF WILLIAMS SYNDROME. Genet Couns. 2015;26(4):437-42.
21- Atik T, Aykut A, Hazan F, Onay H, Goksen D, Darcan S, Tukun A, Ozkinay F. Mutation Spectrum and Phenotypic Features in Noonan Syndrome with PTPN11 Mutations: Definition of Two Novel Mutations. Indian J Pediatr. 2016;83(6):517-21
22- Öner T, Özdemir R, Hazan F, Karadeniz C, Doksoz Ö, Yilmazer MM, Meşe T, Tavli V. The association between brain natriuretic peptide and tissue Doppler parameters in children with hypertrophic cardiomyopathy. Bosn J Basic Med Sci. 2016;16(1):58-63.
23- Korkmaz HA, Demir K, Hazan F, Yıldız M, Elmas ÖN, Özkan B. Association of Wolfram syndrome with Fallot tetralogy in a girl. Arch Argent Pediatr. 2016 ;114(3):e163-6.
24- Parıltay E, Hazan F, Ataman E, Demir K, Etlik Ö, Özbek E, Özkan B. A novel splice site mutation of FGD1 gene in an Aarskog-Scott syndrome patient with a large anterior fontanel. J Pediatr Endocrinol Metab. 2016 ;29(9):1111-4.
25- Koehler K, Milev MP, Prematilake K, Reschke F, Kutzner S, Jühlen R, Landgraf D, Utine E, Hazan F, Diniz G, Schuelke M, Huebner A, Sacher M. A novel TRAPPC11 mutation in two Turkish families associated with cerebral atrophy, global retardation, scoliosis, achalasia and alacrima. J Med Genet. 2016 Oct 5. pii: jmedgenet-2016-104108.
26- Diniz G, Tekgul H, Hazan F, Yararbas K, Tukun A. Sarcolemmal deficiency of sarcoglycan complex in an 18-month-old Turkish boy with a large deletion in the beta sarcoglycan gene. Balkan J Med Genet. 2016;18(2):71-76.
27- Hazan F, Korkmaz HA, Yararbaş K, Wuyts W, Tükün A. Trichorhinophalangeal syndrome type II presenting with short stature in a child. Arch Argent Pediatr. 2016;114(6):e403-e407.
28- Karapınar TH, Yılmaz Karapinar D, Oymak Y, Ay Y, Demirağ B, Aykut A, Onay H, Hazan F, Aydınok Y, Özkınay F, Vergin C. HAX1 mutation positive children presenting with haemophagocytic lymphohistiocytosis. Br J Haematol. 2017;177(4):597-600.
29- Tunç S, Demir K, Tükün FA, Topal C, Hazan F, Sağlam B, Nalbantoğlu Ö, Yıldız M, Özkan B. Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents. J Clin Res Pediatr Endocrinol. 2017;9(3):216-221.
30- Katipoğlu N, Karapinar TH, Demir K, Aydin Köker S, Nalbantoğlu Ö, Ay Y, Korkmaz HA, Oymak Y, Yıldız M, Tunç S, Hazan F, Vergin C, Ozkan B. Infantile-onset thiamine responsive megaloblastic anemia syndrome with SLC19A2 mutation: a case report. Arch Argent Pediatr. 2017;115(3):e153-e156.
31- Vahabi A, Hazan F, Rad IA. A Case Report of 9p Deletion Syndrome Associated with Partial Trisomy of 1q42.Maedica (Buchar). 2017;12(1):55-58.
32- Hazan F, Aykut A, Serdaroğlu G, Gökben S, Akın H, Çoğulu Ö, Özkınay F.Angelman Sendromu: bir olgu sunumu. Ege Journal of Medicine 2009;48(3):195-98.
33- Hazan F, Apa H, Demir K, Böber E, Özkinay F. Silver-Russell Sendromu. (Olgu Sunumu). Fırat Tıp Dergisi. 2012; 1:60-62.
34- Hazan F, Olukman Ö, Şahin F.Ç, Çalkavur Ş, Meşe T, Tavli V, Atlihan F. Pateu Sendromlu üç olgu; klinik triad (mikroftalmi, yarık dudak/damak, polidaktili) her zaman eşlik eder mi? Ege Journal of Medicine 2013;52:104-108.
35- Hazan F, Dursun G, Itirli G, Yalaza C, Onay H, Akercan F, Ozkinay F. Beta talasemi major prenatal tani analizi yapilan üçüz olgu. Ege Journal of Medicine 2013; 52:45-48.
36- Hazan F, Orkide O, Celegen M, Tukun A. Hasta ve aileye genetik yaklaşım: MECP2 geninde p.R270X mutasyonu olan Rett Sendromlu olgu. Turk J Bioch. 2013; 38(1):109-
37- Dizdarer C, Korkmaz HA, Genel F, Hazan F, Ünal N. Psödohipoaldosteronizm: Olgu Sunumu. Smyrna Tıp Dergisi2013;40-42.
38- Ozdemir R, Karadeniz C, Hazan F, Yozgat Y, Doksoz O, Demirol M, Meşe T, Yılmazer MM. Nadir Bir Birliktelik: Klippel-Feil Sendromu ve Dilate Kardiyomiyopati. 2013;