T.C. MİNİSTRY OF HEALTH İZMİR PROVINCIAL HEALTH DIRECTORATE S.B.Ü. DR.BEHÇET UZ CHİLDREN'S EDUCATİON AND RESEARCH HOSPİTAL
T.C. MİNİSTRY OF HEALTH İZMİR PROVINCIAL HEALTH DIRECTORATE S.B.Ü. DR.BEHÇET UZ CHİLDREN'S EDUCATİON AND RESEARCH HOSPİTAL

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Nesrin Gülez, M.D.

Updated: 01/02/2019

1. NAME SURNAME: NESRİN GÜLEZ

2. THE BIRTHDAY:     1969

 PEDIATRIC IMMUNOLOGIST

I was born in Manisa in 1969. I completed my primary and secondary education in Manisa. I gaduated from Ege University Faculty of Medicine in 1992. Between 1992 and 1993, I worked as a general practitioner . In December 1993, Behçet Uz Children Has. I have started Child Health and Diseases Assistant.In 1998, I became a Md as  Child Health and Disease Specialist . I started working in Karsiyaka Mother and Child Health Center in 1998 as a for 3 years. While I was here, I personally served in Polio eradication studies. In 2001, Behçet Uz Children Hospital. . I was successful by taking the first exam and started working as the Chief Physician of Child Health and Diseases. Until 2007, I worked as in Neonatal Intensive Care, Infectious Diseases and Emergency Department. Since 2003, I have been active in Immunology Polyclinics. I was trained in flow-cytometric diagnosis and started flow cytometric evaluation in the diagnosis of primary immunodeficiencies. In October 2007, Ege Ü. Medical Faculty, Department of Child Health and Diseases I have been involved in a number of studies on primary immunology. On February 25, 2011, I received in Pediatric Immunology. Dr. Behçet Uz Children Has. Hospital. I've been appointed as a specialist in pediatrics immunology. In the same year, I was assigned to Pediatric Rheumatology outpatient clinic. On February 8, 2013, I won the title of Associate Professor in Pediatric Immunology. Since then, I worked in Pediatric Immunology. I am still continuing to work  by taking the title of Child Allergy- Immunology Education Officer in 14/5/2014. In the rheumatology polyclinics I served rheumatology patients between the years 2011-2016. Child Immunology Polyclinic, Immunology Service is active in my studies.

. ARTICLES PUBLISHED IN INTERNATIONAL REFEREED JOURNALS (SCI & SSCI & ARTS AND HUMANITIES)

1: Hortu HO, Karaca E, Sozeri B, Gulez N, Makay B, Gunduz C, Atik T, Tekin IM, Unsal SE, Cogulu O. Correction to: Evaluation of the effects of miRNAs in familial Mediterranean fever. Clin Rheumatol. 2019 Jan 7. doi:10.1007/s10067-018-04409-w. [Epub ahead of print] PubMed PMID: 30617595.

2: Genel F, Erdem SB, Gülez N, Karaman S, Nacaroglu HT, Skattum L, Truedsson L.Inherited Classical and Alternative Pathway Complement Deficiencies in Children: A Single Center Experience. Iran J Immunol. 2018 Dec;15(4):309-320. doi:10.22034/IJI.2018.39400. PubMed PMID: 30593745.

3: Gülez N, Makay B, Sözeri B. Long-Term Effectıveness and Safety of Canakınumab ın Pedıatrıc Famılıal Medıterranean fever patıents. Mod Rheumatol. 2018 Dec 17:1-13. doi: 10.1080/14397595.2018.1559488. [Epub ahead of print] PubMed PMID:30556769.

4: Karaca NE, Severcan EU, Bilgin BG, Azarsiz E, Akarcan S, Gunaydın NC, Gulez N,Genel F, Aksu G, Kutukculer N. Familial inheritance and screening of first-degree relatives in common variable immunodeficiency and immunoglobulin A deficiency patients. Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418779458. doi: 10.1177/2058738418779458. PubMed PMID: 29978731; PubMed

5: Pfajfer L, Mair NK, Jiménez-Heredia R, Genel F, Gulez N, Ardeniz Ö, Hoeger B, Bal SK, Madritsch C, et al.

 Mutations affecting the actin regulator WD repeat-containing protein 1 lead to aberrant lymphoid immunity. J Allergy Clin Immunol. 2018Nov;142(5):1589-1604.e11. doi: 10.1016/j.jaci.2018.04.023. Epub 2018 May 8.

6: Karaman S, Erdem SB, Gülez N, Genel F. The Significance of B-cell Subsets in Patients with Unclassified Hypogammaglobulinemia and Association with Intravenous Immunoglobulin Replacement Requirement. Iran J Immunol. 2018 Mar;15(1):1-13. doi:IJIv15i1A1. PubMed PMID: 29549228.

7: Hortu HO, Karaca E, Sozeri B, Gulez N, Makay B, Gunduz C, Atik T, Tekin IM,Unsal SE, Cogulu O. Evaluation of the effects of miRNAs in familial Mediterranean fever. Clin Rheumatol. 2018 Feb 13. doi: 10.1007/s10067-017-3914-0. [Epub ahead of print] Erratum in: Clin Rheumatol. 2019 Jan 7;:. PubMed PMID: 29442258.

8: Makay B, Gülez N. Long-term follow-up of paediatric MEFV carriers. Clin Rheumatol. 2018 Jun;37(6):1683-1687. doi: 10.1007/s10067-017-3883-3. Epub 2017Nov 3. PubMed PMID: 29101676.

9: Nacaroğlu HT, Bahçeci Erdem S, Gülez N, Ünsal Karkıner CŞ, Devrim İ, Genel F, Köker MY, Can D. Tuberculosis masked by immunodeficiency: a review of two cases diagnosed with chronic granulomatous disease. Tuberk Toraks. 2017 Mar;65(1):56-59. PubMed PMID: 28621249.

10: Kundak S, Bağ Ö, Gülez N, Ergin M. A child with subcorneal pustular dermatosis responded to IVIG treatment (Sneddon-Wilkinson disease). Reumatologia. 2017;55(6):323-327. doi: 10.5114/reum.2017.72631. Epub 2017 Dec 30. PubMed PMID: 29491542;

11: Karaca NE, Aksu G, Ulusoy E, Aksoylar S, Gozmen S, Genel F, Akarcan S, Gulez N, Hirschmugl T, Kansoy S, Boztug K, Kutukculer N. Early Diagnosis and Hematopoietic Stem Cell Transplantation for IL10R Deficiency Leading to Very Early-Onset Inflammatory Bowel Disease Are Essential in Familial Cases. Case

Reports Immunol. 2016;2016:5459029. Epub 2016 Sep 6.

12: Sozeri B, Gulez N, Ergin M, Serdaroglu E. The experience of canakinumab in renal amyloidosis secondary to Familial Mediterranean fever. Mol Cell Pediatr.2016 Dec;3(1):33. doi: 10.1186/s40348-016-0058-2. Epub 2016 Aug 15.

13: Keles S, Charbonnier LM, Kabaleeswaran V, Reisli I, Genel F, Gulez N, Al-Herz W, Ramesh N, Perez-Atayde A, Karaca NE, Kutukculer N, Wu H, Geha RS, Chatila TA. Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes T(H)17 cell differentiation. J Allergy

Clin Immunol. 2016 Nov;138(5):1384-1394.e2. doi: 10.1016/j.jaci.2016.04.023. Epub 2016 May 24. PubMed PMID: 27350570; PubMed Central PMCID: PMC5099100.

14: Polat A, Acikel C, Sozeri B, Dursun I, Kasapcopur O, Gulez N, Simsek D,Saldir M, Dokurel I, Poyrazoglu H, Bakkaloglu S, Delibas A, Ekinci Z, Ayaz NA,Kandur Y, Peru H, Kurt YG, Polat SR, Unsal E, Makay B, Gok F, Ozen S, Demirkaya E; FMF Arthritis Vasculitis and Orphan Disease Research in Pediatric Rheumatology

(FAVOR). Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever--a randomized controlled noninferiority trial. Arthritis Res Ther. 2016 Apr 7;18:85. doi: 10.1186/s13075-016-0980-7. PubMed PMID: 27055417;

15: Erdem SB, Genel F, Erdur B, Ozbek E, Gulez N, Mese T. Asplenia in children with congenital heart disease as a cause of poor outcome. Cent Eur J Immunol. 2015;40(2):266-9. doi: 10.5114/ceji.2015.52841. Epub 2015 Aug 3.

16: Bahceci SE, Genel F, Gulez N, Nacaroglu HT. Coexistence of hereditary angioedema in a case of familial Mediterranean fever with partial response to colchicine. Cent Eur J Immunol. 2015;40(1):115-6. doi: 10.5114/ceji.2015.50843.Epub 2015 Apr 22. PubMed PMID: 26155193; .

17: Azarsiz E, Karaca NE, Gunaydin NC, Gulez N, Ozturk C, Aksu G, Genel F,Kutukculer N. Do elevated serum IgM levels have to be included in probablediagnosis criteria of patients with ataxia-telangiectasia? Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(3):421-7. PubMed PMID: 25280033.

18: Yılmaz U, Gülez N, Cubukçu D, Güzel O, Akinci G, Oztürk A. Recurrent peripheral facial palsy in a child with familial Mediterranean fever. Pediatr Neurol. 2013 Oct;49(4):289-91. doi: 10.1016/j.pediatrneurol.2013.05.003. Epub2013 Jul 6. PubMed PMID: 23838413.

19: Kutukculer N, Gulez N, Karaca NE, Aksu G, Berdeli A. Three different classifications, B lymphocyte subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CTLA-4 and ICOS gene polymorphisms in Turkish patients with common variable immunodeficiency. J Clin Immunol. 2012Dec;32(6):1165-79. doi: 10.1007/s10875-012-9717-9. Epub 2012 Jun 15.

20: Kutukculer N, Gulez N, Karaca NE, Aksu G, Berdeli A. Novel mutatıons and diverse clinical phenotypes in recombinase-activating gene 1 deficiency. Ital J Pediatr. 2012 Mar 16;38:8. doi: 10.1186/1824-7288-38-8. PubMed PMID: 22424479; PubMed Central PMCID: PMC3394211.

21: Sozeri B, Gulez N, Aksu G, Kutukculer N, Akalın T, Kandiloglu G.Pesticide-induced scleroderma and early intensive immunosuppressive treatment.Arch Environ Occup Health. 2012;67(1):43-7. doi: 10.1080/19338244.2011.564231.PubMed PMID: 22315935.

22: Ozturk C, Halicioglu O, Coker I, Gulez N, Sutçuoglu S, Karaca N, Aksu G,Kutukculer N. Association of clinical and genetical features in FMF with focus on MEFV strip assay sensitivity in 452 children from western Anatolia, Turkey. Clin Rheumatol. 2012 Mar;31(3):493-501. doi: 10.1007/s10067-011-1876-1. Epub 2011 Nov 5. PubMed PMID: 22057232.

23: Genel F, Atlihan F, Gulez N, Kazanci E, Vergin C, Terek DT, Yurdun OC.Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocytes of peripheral blood for early diagnosis of neonatal infection. World J Pediatr. 2012 Feb;8(1):72-5. doi: 10.1007/s12519-011-0304-6. Epub 2011 Aug 27.

24: Karaca NE, Gulez N, Aksu G, Azarsiz E, Kutukculer N. Does OM-85 BV prophylaxis trigger autoimmunity in IgA deficient children? Int Immunopharmacol. 2011 Nov;11(11):1747-51. doi: 10.1016/j.intimp.2011.06.009. Epub 2011 Jul 21.PubMed PMID: 21771668.

25: Kutulculer N, Karaca NE, Azarsiz E, Aksu G, Gulez N. Immunoglobulin light chain levels can be used to determine disease stage in children with juvenile idiopathic arthritis. Clin Lab Sci. 2011 Spring;24(2):93-8. PubMed PMID:21657141.

26: Gulez N, Aksu G, Berdeli A, Karaca N, Tanrıverdi S, Kutukculer N, Azarsiz E. X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency MayNot Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis. Case Rep Med. 2011;2011:121258. doi: 10.1155/2011/121258. Epub 2011 Apr 12. PubMed PMID:21541208;

27: Karaca NE, Durandy A, Gulez N, Aksu G, Kutukculer N. Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature. Eur J Pediatr. 2011 Aug;170(8):1039-47. doi:10.1007/s00431-011-1400-2. Epub 2011 Jan 28. Review.

28: Karaca NE, Aksu G, Gulez N, Yildiz B, Azarsiz E, Kutukculer N. New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. Iran J Allergy Asthma Immunol. 2010 Dec;9(4):237-43. doi: 09.04/ijaai.237243. PubMed PMID: 21131704.

29: Karaca N, Aksu G, Ozturk C, Gulez N, Kutukculer N. Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis triggered by vaccinations in a two-year-old boy: a case report. J Med Case Rep. 2010 Oct 18;4:325. doi:10.1186/1752-1947-4-325. PubMed PMID: 20955551;

30: Azarsiz E, Gulez N, Edeer Karaca N, Aksu G, Kutukculer N. Consanguinity rate and delay in diagnosis in Turkish patients with combined immunodeficiencies: a single-center study. J Clin Immunol. 2011 Feb;31(1):106-11. doi:10.1007/s10875-010-9472-8. Epub 2010 Oct 6. PubMed PMID: 20924659.

31: Gulez N, Genel F, Atlihan F, Gullstrand B, Skattum L, Schejbel L, Garred P,Truedsson L. Homozygosity for a novel mutation in the C1q C chain gene in a Turkish family with hereditary C1q deficiency. J Investig Allergol Clin Immunol. 2010;20(3):255-8. PubMed PMID: 20635792.

32: Aksu G, Gulez N, Azarsiz E, Karaca N, Kutukçuler N. Determination of cut-off titers and agreement between immunofluorescence and immunoblotting methods for detecting antinuclear antibodies in children. J Clin Lab Anal. 2010;24(4):230-6. doi: 10.1002/jcla.20391. PubMed PMID: 20626019.

33: Edeer-Karaca N, Gülez N, Aksu G, Kütükcüler N. Common variable immunodeficiency: familial inheritance and autoimmune manifestations in two siblings. Turk J Pediatr. 2010 Jan-Feb;52(1):89-93. PubMed PMID: 20402074.

34: Kutukculer N, Gulez N, Karaca N, Aksu G, Berdeli A. A novel Y331X nonsensenmutation in TNFRSF1A gene in two unrelated Turkish families with periodic fever syndrome. Int J Immunogenet. 2010 Feb;37(1):21-5. doi:10.1111/j.1744-313X.2009.00884.x. Epub 2009 Oct 5. PubMed PMID: 19804406.

35: Karaca NE, Aksu G, Genel F, Gulez N, Can S, Aydinok Y, Aksoylar S, Karaca E, Altuglu I, Kutukculer N. Diverse phenotypic and genotypic presentation of RAG1 mutations in two cases with SCID. Clin Exp Med. 2009 Dec;9(4):339-42. doi: 10.1007/s10238-009-0053-1. Epub 2009 May 21. PubMed PMID: 19458910.

36: Karaca NE, Aksu G, Yildiz B, Gulez N, Turk B, Dereli T, Kutukculer N. Relapsing polychondritis in a child with common variable immunodeficiency. Int J  Dermatol. 2009 May;48(5):525-8. doi: 10.1111/j.1365-4632.2009.03809.x.

37: Kutukculer N, Gulez N. The outcome of patients with unclassified hypogammaglobulinemia in early childhood. Pediatr Allergy Immunol. 2009 Nov;20(7):693-8. doi: 10.1111/j.1399-3038.2008.00845.x. Epub 2009 Jan 31. PubMed PMID: 19196447.

38: Gulez N, Karaca NE, Aksu G, Kutukculer N. Increased percentages of autoantibodies in immunoglobulin A-deficient children do not correlate with clinical manifestations. Autoimmunity. 2009 Jan;42(1):74-9. doi: 10.1080/08916930802375711. PubMed PMID: 19127458.

39: Genel F, Atlihan F, Gulez N, Sjöholm AG, Skattum L, Truedsson L. Properdin deficiency in a boy with fulminant meningococcal septic shock. Acta Paediatr. 2006 Nov;95(11):1498-1500. PubMed PMID: 17062484.

40: Genel F, Atlihan F, Targan S, Gulez N, Hacikara S, Karaca I. Fulminant amoebiasis in a child with recurrent multiple amoebic liver abscesses and pleuropulmonary complications. Ann Trop Paediatr. 2004 Sep;24(3):267-9.